The system can be used in the same way against a 5:1 defense, and a good basic rule is, that the backcourt and wing player runs parallel each time CB opens up for a center cross. It opens for more variations.
Here is the most simple form of the Trailer.
CB has 2 options. She can pass to LB or LW, who both can shoot with a jump shot in front of the screening.
The pass from LW can go directly to CB. It gives a different rhythm in the play and LW must take care not to run in too "flat"

In this example the play is this:
CB receives the ball and runs against the defending R2 and sets a screening.
During this run CB pass the ball to the running in LB
LB runs parallel with LW
LB shoots.